Genetic modifiers of cardiac electrophysiology in a large Dutch family with the SCN5A 1795insD mutation

Genetic modifiers of cardiac electrophysiology in a large Dutch family with the SCN5A 1795insD mutation - Genetic modifiers of cardiac electrical phenotype

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30585

Enrollment

Registered

2007-03-08

Start date

2007-03-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary arrhythmia syndromes - heritable heart rhythm disorders

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Having conceived 1 or more children carrying the SCN5A 1795insD mutation with someone who is also carrying this mutation (i.e. the individual is a spouse and parent of a mutation carrier)

Exclusion criteria

Exclusion criteria: No informed consent

Design outcomes

Primary

Measure	Time frame
The discovery of genetic modifiers which are associated with the cardiac electrical phenotype and SCD may allow improved risk stratification and individualised tailoring of preventive and therapeutic treatment not only for the SCN5A 1795insD family but also for other populations at risk for SCD.	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results