Genetic origin of Dupuytren*s disease and associated fibromatosis

Genetic origin of Dupuytren*s disease and associated fibromatosis - GODDAF

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30567

Enrollment

600

Registered

2007-05-29

Start date

2007-06-05

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dupuytren's disease Ledderhose's disease Peyronie's disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Gene expression study: 1.Clinically confirmed diagnosis of Dupuytren*s, Peyronie*s or Ledderhose*s disease 2.Patient for which selective fasciectomy or plaque excision/biopsy is part of standard treatment 3.Evident cord AND node at physical examination (only for patients with Dupuytren*s disease) 4. Age >= 18;Gene expression study Dupuytren controls: 1.Confirmed diagnosis of Carpal Tunnel Syndrome 2.Patient for which carpal tunnel release is part of standard treatment 3.Age >= 18;Gene expression study Peyronie controls: 1.Patient receiving penile prosthesis implants for erectile dysfunction or patient having penis amputation 2.Age >= 18;Pedigree analysis and association study: 1.Clinically confirmed diagnosis of Dupuytren*s disease, Peyronie*s disease or Ledderhose*s disease 2.Having relatives with one of these diseases (only for pedigree analysis) 3.Age >= 18;Pedigree analysis family of proband: 1. Age >= 18;Association study controls: 1.Age >= 18

Exclusion criteria

Exclusion criteria: Gene expression study: 1.Post-surgical recurrence 2.Patients unfit to undergo surgery;Gene expression study Dupuytren controls: 1.Diagnosis of Dupuytren*s, Peyronie*s or Ledderhose*s disease or a positive family history for one of these diseases;Gene expression study Peyronie controls: 1.Diagnosis of Dupuytren*s, Peyronie*s or Ledderhose*s disease or a positive family history for one of these diseases;Pedigree analysis and association study: None;Pedigree analysis family of proband: None;Association study controls: 1.Diagnosis of Dupuytren*s disease, Peyronie*s disease or Ledderhose*s disease or a positive family history for one of these diseases

Design outcomes

Primary

Measure	Time frame
Finding the causative gene(s) of the different fibromatosis. Increasing understanding of the etiology/pathology of the diseases and there relation to each other.	—

Secondary

Measure	Time frame
...	—

Countries

Netherlands

Outcome results