Brain development, brain functioning, growth and metabolic aspects in the clinical management of transsexual adolescents.

Brain development, brain functioning, growth and metabolic aspects in the clinical management of transsexual adolescents. - clinical study on transsexual adolescents

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30547

Enrollment

244

Registered

2007-04-17

Start date

2007-01-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gender identity disorder transsexuality

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria pubertal patients: girls and boys with transsexualism who are eligible for sex reassignment according to psychologist and psychiatrist (if they are older than 12 years, psychologically stable and live in a stable social environment) . Girls have to be in stage B2 and boys in G2-G3 with measurable estradiol and testosterone levels respectively. Inclusion criteria pre-pubertal patients: girls and boys with high probability of transsexualism according to psychologist or psychiatrist and the age of 9-12 years. Girls have to be in an earlier stage than B2 and boys in an earlier stage than G2-G3. Inclusion criteria healthy subjects: girls and boys who are similar aged friends of transsexual patients

Exclusion criteria

Exclusion criteria: Exclusion criteria patients: intersex conditions Exclusion criteria healthy subjects: puberty delaying treatment or hormonal therapy, oral anticonception users are not excluded

Design outcomes

Primary

Measure	Time frame
* Cognition: performance and reaction time on three cognition tasks (verbal fluency task, mental rotation task and emotional faces task) * Functional MRI: data during the verbal fluency task, mental rotation task and emotional faces task. * Structural MRI: data on total brain volume, gray and white matter (amount and percentage), CSF, volume frontal and temporal lobe, gyrification, brain asymmetry. ROI analysis of basal ganglia, amygdala, hippocampus, corpus callosum, hypothalamus	—

Measure

Time frame

* Cognition: performance and reaction time on three cognition tasks (verbal fluency task, mental rotation task and emotional faces task) * Functional MRI: data during the verbal fluency task, mental rotation task and emotional faces task. * Structural MRI: data on total brain volume, gray and white matter (amount and percentage), CSF, volume frontal and temporal lobe, gyrification, brain asymmetry. ROI analysis of basal ganglia, amygdala, hippocampus, corpus callosum, hypothalamus

—

Secondary

Measure	Time frame
* score from -10 to 10 on handedness questionairre * performance score on adapted WISC-III questionairre (4 items: 2 performance, 2 verbal) * information about psychological functioning (parent questionairre) * anthropometric data, information about pubertal stage according to Tanner * information about homosexuality/ transsexuality in familymembers * digital photographs and physical appearance list (14 items)	—

Measure

Time frame

* score from -10 to 10 on handedness questionairre * performance score on adapted WISC-III questionairre (4 items: 2 performance, 2 verbal) * information about psychological functioning (parent questionairre) * anthropometric data, information about pubertal stage according to Tanner * information about homosexuality/ transsexuality in familymembers * digital photographs and physical appearance list (14 items)

—

Countries

Netherlands

Outcome results