Dynamics of the innate, cellular and humoral immune response in healthy persistent, intermittent and noncarriers of Staphylococcus aureus

Dynamics of the innate, cellular and humoral immune response in healthy persistent, intermittent and noncarriers of Staphylococcus aureus - STAIR study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30541

Enrollment

400

Registered

2007-06-05

Start date

2007-09-03

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nasal colonisation Staphylococcus aureus

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy individuals older than 18 years The volunteer has given informed consent

Exclusion criteria

Exclusion criteria: Individuals with age below 18 years Volunteers with diabetes mellitus, renal insufficiency, COPD, heart diseases, immunocompromised status (HIV, AIDS) or use of immunosuppressants, skin diseases like eczema and psoriasis.

Design outcomes

Primary

Measure	Time frame
1. The amount of persistent, intermittent and noncarriers 2. The qualitative or quantitative difference in the presence of antistaphylococcal IgG, IgM and IgA between healthy persistent, intermittent and noncarriers of S. aureus in blood or nasal secretion 3. The qualitative or quantitative difference in the presence of CD4+ and CD8+ T cells between healthy persistent, intermittent and noncarriers of S. aureus in blood 4. The difference in protein composition of nasal secretion between healthy persistent, intermittent and noncarriers of S. aureus 5. The qualitative or quantitative difference in the presence of antistaphylococcal antibodies and cellular immune response between healthy individuals compared to patients with a bacteremia caused by S. aureus	—

Measure

Time frame

1. The amount of persistent, intermittent and noncarriers 2. The qualitative or quantitative difference in the presence of antistaphylococcal IgG, IgM and IgA between healthy persistent, intermittent and noncarriers of S. aureus in blood or nasal secretion 3. The qualitative or quantitative difference in the presence of CD4+ and CD8+ T cells between healthy persistent, intermittent and noncarriers of S. aureus in blood 4. The difference in protein composition of nasal secretion between healthy persistent, intermittent and noncarriers of S. aureus 5. The qualitative or quantitative difference in the presence of antistaphylococcal antibodies and cellular immune response between healthy individuals compared to patients with a bacteremia caused by S. aureus

—

Countries

Netherlands

Outcome results