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Nocturnal excretion of cortisol, CRH and catecholamines, and their relation to sleep EEG in deployment related posttraumatic stress disorder (PTSD)

Nocturnal excretion of cortisol, CRH and catecholamines, and their relation to sleep EEG in deployment related posttraumatic stress disorder (PTSD) - sleependocrinology in PTSD

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON30459
Enrollment
60
Registered
2007-06-19
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

posttraumatic stress disorder trauma

Interventions

None listed

Sponsors

Universitair Medisch Centrum Utrecht
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: male, age 18-65, CAPS > 50 (patients)

Exclusion criteria

Exclusion criteria: substance /alcoholabuse within 6 months psychotrophic medication chronical benzodiazepin use History of psychiatric disorder (controls), CAPS > 18 (contorls)

Design outcomes

Primary

MeasureTime frame
The primary outcome measure is number of awakenings of plasma cortisol concentrations.—

Secondary

MeasureTime frame
Secondary objectives are 1. Other PSG parameters 2. Nocturnal excretion of catecholamines and hormones of the HPA axis in 3. Correlations of plasma concentration of catecholamines and hormones of the HPA axis with number of arousals and other PSG parameters 4. Correlation of subjective sleep complaints with number of awakenings and other PSG parameters 5. Correlation of objective and subjective sleep quality with general psychological and somatic well being, according to *Symptom Checklist - 90* (SCL-90) and *Checklist Individuele Spankracht* (CIS). 6. Correlation of sleep endocrinology with temperament and personality, as measured by *Temperament and Character Inventory*. 7. Awakening response curve of cortisol and ACTH in PTSD compared with controls—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)