strabismus squint
Conditions
Interventions
Diluted PI, 1.25% or 5%, will be prepared in a sterile fashion, and distributed
in single-use dispensers. These will be coded for randomization. Before
initiation of surgery, children randomized to
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: (1) Children
Exclusion criteria
Exclusion criteria: (1) Any history or current condition of hypersensitivity to iodine. (2) Children on topical antibiotic within the last 30 days. (3) Children with signs of acute conjunctivitis, blepharitis, dacryocystitis or respiratory infection within the last 30 days. (4) Children with asthma or similar chronic, obstructive pulmonary disorder (5) Insufficiently treated amblyopia, i.e. visual acuity must be equal in both eyes or not differ by more than 1 LogMAR line (or equivalent in preverbal children).
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Iodine excretion after surgery, assessed as urine iodine concentration per creatinine clearance. Postoperative erosion of the cornea and corneal oedema. Both of these have been described as side-effects of PI use. | — |
Primary
| Measure | Time frame |
|---|---|
| The difference in the mean numbers of bacterial colony forming units (CFUs) from pre-irrigation (l) to post-irrigation with PI (2-4). | — |
Countries
Netherlands
Outcome results
None listed