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Cytokines in dermal interstitial fluid after single and repeated skin irritation

Cytokines in dermal interstitial fluid after single and repeated skin irritation - Cytokines in dermal interstitial fluid

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON30412
Enrollment
10
Registered
2006-04-19
Start date
2006-03-24
Completion date
Unknown
Last updated
2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Academisch Medisch Centrum
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - age between 18 and 55 years - Caucasian

Exclusion criteria

Exclusion criteria: - skin diseases - sunbathing or using a tanning bed 2 months prior to, and during, the investigation - use of inflammation suppressing medicines (e.g. corticosteroids, NSAIDs) or antibiotics one week prior to, and during the investigation

Design outcomes

Primary

MeasureTime frame
To monitor the skin reaction during and after the above mentioned exposures, we will use transepidermal water loss (TEWL) as an effect parameter for the skin barrier function and erythema for the extent of skin inflammation. The ISF samples will be analysed for the cytokines IL-1a, IL-1RA, IL-1β, IL-2, IL-6, IL-8, IL-10 and TNF-a using ELISA.—

Secondary

MeasureTime frame
n.a.—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)