Endothelial function in Systemic Lupus Erythematosus and Wegener's granulomatosis: associations with traditional and non-traditional cardiovascular risk factors

Endothelial function in Systemic Lupus Erythematosus and Wegener's granulomatosis: associations with traditional and non-traditional cardiovascular risk factors - Endothelial function in SLE and WG

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30402

Enrollment

160

Registered

2006-12-28

Start date

2006-12-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atherosclerosis cardiovascular disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: SLE patients: - fulfil the American College of Rheumatology criteria for SLE - 20-65 years of age;WG patients: - fulfil the American College of Rheumatology criteria for WG - 20-65 years of age;Patients with essential hypertension - blood pressure of 140/90 mmHg or more - age and sex matched to SLE patients;Healthy controls: - age and sex matched to SLE patients

Exclusion criteria

Exclusion criteria: - pregnancy - diabetes mellitus - renal impairment - MI or sepsis in the past three months - recent surgery - clinical history of cardiovascular disease - cardiovascular conditions that can produce altered blood pressure waveforms: arrythmias, valvular heart disease or congestive heart failure;SLE patients: - Raynaud's phenomenon

Design outcomes

Primary

Measure	Time frame
Small Artery Elasticity (SAE), Large Artery Elasticity (LAE), Intima Media Thickness (IMT), EC Activation Markers (TM, sVCAM-1, vWF, homocysteine, oxLDL, hsCRP), Advanced Glycation Endproducts (AGE), Endothelial Progenitor Cells (EPC)	—

Secondary

Measure	Time frame
Blood count, ALAT, ASAT, creatinin, cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, CRP, blood pressure, pulse rate, BMI, smoking, family history for CVD	—

Countries

Netherlands

Outcome results