Chronic obstructive pulmonary disease
Conditions
Interventions
We study the influence of n-acetylcysteine and rosuvastatin on the parameters
of systemic inflammation, oxidative stress and muscle breakdown in bloodsamples
of muscle depleted COPD patients, before
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: clinically stable COPD patients (GOLD II, III, IV) with a low fat-free mass (
Exclusion criteria
Exclusion criteria: Exacerbation less than 2 months before the start of the experiment Smoking Oral corticosteroids Long-term oxygen therapy Respiratory insufficiency (PaO2 6,3 kPa) Other chronic exercise limiting disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in parameters of systemic inflammation (concentrations of leukocyts, CRP, IL-6, IL-8, IL-1ra, TNFa) after intervention. Differences in parameters of oxidative stress (ROS-production, plasma antioxidant capacity, protein oxidation, lipid peroxidation, GSSG/GSH-ratio) after intervention. Differences in parameters of muscle damage (troponin I) after intervention. Differences in parameters of muscle breakdown (ubiquitin-proteasome system). Differences in pulmonary parameters and exercise capacity. | — |
Secondary
| Measure | Time frame |
|---|---|
| - | — |
Countries
Netherlands
Outcome results
None listed