painful neuropathy small diameter nerve fibre neuropathy
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 years or older 2. Clinically suspected small fibre neuropathy 3. Normal results of standard nerve-conduction studies or only minor abnormalities not compatible with polyneuropathy
Exclusion criteria
Exclusion criteria: 1. Age under 18 years 2. Symptoms and signs indicating large nerve fibre involvement 3. Nerve conduction studies compatible with polyneuropathy 4. Pre-existent vascular insufficiency, confirmed by echo doppler or a history of ulcus cruris
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| If patients are eligible they will undergo the following baseline investigations: various questionnaires, a general physical and neurological examination, extensive laboratory tests, chest radiograph, the short form QST protocol and a skin biopsy. These investigations are repeated at one and/or two years of follow-up. The results will be compared with eachother. | — |
Countries
Netherlands
Outcome results
None listed