T and NK cell mediated immunotherapy in osteosarcoma; a preclinical feasibility study

T and NK cell mediated immunotherapy in osteosarcoma; a preclinical feasibility study - T and NK cell mediated immunotherapy in osteosarcoma

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30381

Enrollment

Registered

2007-01-23

Start date

2007-01-10

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bone tumors

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: All newly diagnosed osteosarcoma patients in the LUMC Written informed consent

Exclusion criteria

Exclusion criteria: Lack of written informed consent

Design outcomes

Primary

Measure	Time frame
This preclinical study will provide insight in the molecular mechanisms involved in directional migration, recognition and elimination by T/NK cells of osteosarcomas. In addition, we will identify potential immune evasion strategies in OS. Potential differences between autologous and allogeneic effector cells will be identified. Together, this study will provide evidence for the implementation of NK and/or T cell-mediated immunotherapy strategies in future clinical studies.	—

Measure

Time frame

This preclinical study will provide insight in the molecular mechanisms involved in directional migration, recognition and elimination by T/NK cells of osteosarcomas. In addition, we will identify potential immune evasion strategies in OS. Potential differences between autologous and allogeneic effector cells will be identified. Together, this study will provide evidence for the implementation of NK and/or T cell-mediated immunotherapy strategies in future clinical studies.

—

Countries

Netherlands

Outcome results