Does ACE phenotype predict the acute antihypertensive response to ACE inhibition?

Does ACE phenotype predict the acute antihypertensive response to ACE inhibition? - not available

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON30335

Enrollment

Registered

2006-11-10

Start date

2007-03-01

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypertensie arterial hypertension high blood pressure

Interventions

The interventions consist of administration of a single oral dose of an ACE-inhibitor or placebo as well a administration of a single oral dose of an ACE-inhibitor after pretreatment with a thiazide

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Essential hypertension grade 1 or 2 Age 18-70 yrs Male or female

Exclusion criteria

Exclusion criteria: History of cardiovascular disease Secondary forms of hypertension Grade 3 hypertension Pregnancy or nursing

Design outcomes

Primary

Measure	Time frame
Relation between plasma ACE level (ACE-phenotype) and, placebo-controlled, acute antihypertensive response before and after preadministration of a thiazide diuretic.	—

Secondary

Measure	Time frame
Effect of ACE gene polymorfism (ID, DD and II) on plasma ACE-level.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)