psoriasis rheumatoid arthritis
Conditions
Interventions
The intervention study is a randomized controlled trial. Half of all
participants with respectively a high and low risk profile for stress will be
asked to participate in a stress management interve
ca. 1
hour each session). During these visits participants are offered relaxation
therapy. Additionally, they will get homework assignments (15 minutes each
day). The control groups (half of all RA
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with rheumatoid arthritis (Arnett et al., 1988) or psoriasis (van de Kerkhof, 2003). This criterion is not applicable to healthy controls 18 years or older Informed consent
Exclusion criteria
Exclusion criteria: Severe physical comorbid conditions (e.g. psoriatic arthritis, malignancy, renal insufficiency) Psychiatric disturbances that interfere with the study protocol pregnancy non-Dutch speakers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psychological distress (anxiety and depression) | — |
Secondary
| Measure | Time frame |
|---|---|
| Fysiologic assessments: concentrations cortisol, ACTH, IL-1, IL-6, IL-18, MIF en TNF-alfa Other measurements: - Clinical assessment of disease activity (DAS or PASI) - Autonomous stress response (heart rate variability and skin conductance) - Self-reported variables (using standardized questionnaires) such as self-reported disease activity, physical symptoms (f.e. pain, itching, fatigue), psychological risk factors and stressors | — |
Countries
Netherlands
Outcome results
None listed