Effect of ischemic postconditioning on targeting of Annexin A5 after forearm exercise

Effect of ischemic postconditioning on targeting of Annexin A5 after forearm exercise - IPost

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON30297

Enrollment

Registered

2007-02-13

Start date

2007-02-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ischemic reperfusion injury myocardial infarction

Interventions

Study 1 ischemic exercise vs non-ischemic exercise of the non dominant forearm Study 2: 10 minute delay between ischemic (exercise) and administration of Annexin A5 and intermittent reperfusion (1

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -Male -Age 18-50 years -No physical limitation to perform ischemic exercise -Informed consent

Exclusion criteria

Exclusion criteria: -Diabetes (fasting glucose >7,0mmol/l, or random glucose >11,0mmol/l) -hyperlipidemia (fasting total cholesterol > 5.5 mmol/l) -Hypertension (supine SBP/DBP > 140/90 mmHg at screening) -Any cardiovascular disease -Drug abuse -Concomittant chronic use of medication -Administration of radioactivity in research setting during the last 5 years -Participation to any drug-investigation during the previous month as checked with VIP check according to CRCN standard procedures.

Design outcomes

Primary

Measure	Time frame
Percentage difference in radioactivity (counts/pixel) between experimental and control thenar muscle at 60 and 240 minutes after reperfusion.	—

Secondary

Measure	Time frame
Workload during (ischemic) exercise.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)