Pulse-Wave Velocity Measurement in Patients with Marfan Syndrome: Automated and Non-Invasive Assessment of the Regional Vascular Status for Risk Stratification

Pulse-Wave Velocity Measurement in Patients with Marfan Syndrome: Automated and Non-Invasive Assessment of the Regional Vascular Status for Risk Stratification - Acquisition of the Elasticity of the aorta with MRI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30274

Enrollment

100

Registered

2007-05-14

Start date

2007-04-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

disturbed compliance of the vascular status Marfan

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with Marfan syndrome with expected regionally impaired aortic wall compliance (eg. with an implanted aortic graft) will be recruited from the patient database at the AMC. Patients already undergoing an angiographic procedure, that are selected for additional pressure measurements and MRI, are recruited at the LUMC. Healthy volunteers will be age- and gender-matched to the Marfan patient population. Other inclusion criterion is the subject*s willingness to undergo (additional) MRI examinations at the LUMC.

Exclusion criteria

Exclusion criteria: Exclusion criteria are the standard MRI exclusion criteria (pacemakers, cerebral vascular clips, metallic splinters in the eye, pregnancy, claustrophobia).

Design outcomes

Primary

Measure	Time frame
This non-invasive approach will demonstrate to be a clinically applicable, accurate and reproducible method with prognostic value for the vascular status of the aorta.	—

Countries

Netherlands

Outcome results