geen aandoening nvt
Conditions
Interventions
Participants will be treated with histidine depletion, tyrosine depletion, or a
placebo. All treatments are provided to the volunteer as a drink. The treatment
order will be established by complete
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: male or female, between 18 and 35 years of age, healthy (absence of exclusion criteria), normal static binocular acuity, body mass index between 18.5 and 30, willingness to sign an informed consent.
Exclusion criteria
Exclusion criteria: history of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological or psychiatric illness, excessive drinking (>20 glasses of alcohol containing beverages a week), pregnancy or lactation, use of medication other than oral contraceptives, use of recreational drugs from 2 weeks before until the end of the experiment, and any sensory or motor deficits which could reasonably be expected to affect test performance. Those volunteers who have a first-degree relative with a psychiatric disorder or a history of a psychiatric disorder will also be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint is the behavioural score on the critical tracking task, a task that measures psychomotor performance. Secondary, the behavioural and event-related potential response during simple and choice reaction time tasks will be analysed. A further important parameter is the change in histidine blood plasma level after histidine depletion. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary are the behavioural and brain activity scores during a verbal learning task, the Sternberg working memory scanning, and a visual oddball paradigm. These tasks enable us to assess the specificity of the effects of histidine depletion. | — |
Countries
Netherlands
Outcome results
None listed