Effect of endoscopic treatments of Barrett's oesophagus on oesophageal motility and reflux

Effect of endoscopic treatments of Barrett's oesophagus on oesophageal motility and reflux - Motility and reflux after endoscopic treatment Barrett

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30256

Enrollment

Registered

2006-12-18

Start date

2007-02-26

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oesophageal motility reflux

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Barrett's oesophagus with high-grade dysplasia Scheduled for endoscopic treatment with SRER or BARRx

Exclusion criteria

Exclusion criteria: Prior surgery of the stomach or oesophagus condition with contraindicates the cessation of PPI therapy such as peptic ulcer disease

Design outcomes

Primary

Measure	Time frame
Using oesophageal manometry the following parameters will be assessed: % of contractions that are peristaltic, contraction amplitude and duration in the proximal and distal oesophagus, lower oesophageal sphincter pressure and relaxation nadir pressure. Impedance-pH measurements will be analyzed for number and type (acid, weakly acidic, liquid, gas or mixed liquid-gas reflux) of reflux episodes and proximal extent of the reflux episodes. In addition, % of time with oesophageal pH	—

Measure

Time frame

Using oesophageal manometry the following parameters will be assessed: % of contractions that are peristaltic, contraction amplitude and duration in the proximal and distal oesophagus, lower oesophageal sphincter pressure and relaxation nadir pressure. Impedance-pH measurements will be analyzed for number and type (acid, weakly acidic, liquid, gas or mixed liquid-gas reflux) of reflux episodes and proximal extent of the reflux episodes. In addition, % of time with oesophageal pH

—

Secondary

Measure	Time frame
-	—

Countries

Netherlands

Outcome results