Correction of thrombin generation in hemophilia plasma by recombinant factor V mutants

Correction of thrombin generation in hemophilia plasma by recombinant factor V mutants - Correction of thrombin generation in hemophilia plasma

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30248

Enrollment

Registered

2006-10-12

Start date

2006-10-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hemophilia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Consenting adult patients with hemophilia A · 10 patients with severe hemophilia A (factor VIII 1.0 Bethesda Units)

Exclusion criteria

Exclusion criteria: Exclusion criteria · Liver disease leading to other coagulopathies · Anemia (Hb

Design outcomes

Primary

Measure	Time frame
Laboratory tests for activation of coagulation: - prothrombin activation fragment F1+2 (ELISA) - thrombin-antithrombin complexes (ELISA) - d-dimer (ELISA) - thrombin generation potential (amidolytic assay) - protein C dependent-thrombin generation potential (amidolytic assay) - routine coagulation tests (aPTT and PT) - factor V coagulant activity (one stage clotting test)	—

Secondary

Measure	Time frame
none	—

Countries

Netherlands

Outcome results