brain activation cortical stress response
Conditions
Interventions
Exposure (1 hour) to carbon naoparticles at a concentration of 40 and 80 ug/m3
or to diesel particles (150 ug/m3) and CAPS (150-300 ug/m3) at different
occasions.
Sponsors
Hogeschool Zuyd
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Age > 18 2. No cardiac impairments 3. Free of neurological and psychopathological impairment, including • Most psychopathologies as diagnosed by DSM-IV criteria (depression, anxiety disorders, attention deficit hyper activity disorder (ADHD), schizophrenia, autistic spectrum disorders (PDD-NOS) • diseases of the central nervous system in general (Parkinson disease, cerebro vascular accident (stroke), multiple sclerosis, amyotrophic lateral sclerosis, epilepsy) • other diseases which are known to affect the QEEG: chronic fatigue syndrome (CFS), fibromyalgia, whiplash, burn-out syndrome, migraine
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. (Time of) use of medication affecting brain activity 2. Extreme fatigue at time of experiment 3. Excessive use of drugs in past or present
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Median Power derived from Fouriertransform of QEEG 2) Proportion of various frekquencies (theta to beta-deel) making up the QEEG 3) de baseline blood-flow in the fingertip, ans flow-changes induced by a local challenge with nitroprusside and acetylcholine. | — |
Secondary
| Measure | Time frame |
|---|---|
| 4) CO-exhalation and allantoine in urine as markers for oxidative stress | — |
Countries
Netherlands
Outcome results
None listed