infarction ischemic reperfusion injury
Conditions
Interventions
10 Volunteers receive coffeine 4mg/kg intravenously just before ischemic
exercise. The other 10 volunteers will receive placebo (0,9% NaCl).
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: healthy males, age between 18-50yr
Exclusion criteria
Exclusion criteria: -any concomittant medication -cardiovascular disease -hypertension (systole > 140 mmHg, diastole > 90 mmHg) -hypercholesterolemia (fasting total cholesterol > 5 mmol/l) -diabetes mellitus (fasting glucose > 7.0 mmol/L or random glucose > 11.0 mmol/L) -asthma(recurrent episodes of dyspnea and wheezing, or usage of prescribed medications: inhalation corticosteroids or B2-agonists) -participation in any clinical trial during the last 60 days prior to this study. -administration of two doses of Annexin A5 (0,1mg; 450MBq) during the last 5 years prior to this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage difference in radioactivity (counts/pixel) between experimental and control thenar muscle at 60 and 240 minutes after reperfusion. | — |
Secondary
| Measure | Time frame |
|---|---|
| Dipyridamole concentration (after 7 days administration of dipyridamole 200mg twice daily), ENT-activity in erythrocytes before and after 7 day treatment with dipyridamole, and workload during ischemic exercise. | — |
Countries
Netherlands
Outcome results
None listed