Effect of 12 weeks training on muscular lipid handling in relation to type 2 diabetes mellitus.

Effect of 12 weeks training on muscular lipid handling in relation to type 2 diabetes mellitus. - Training and lipid handling

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30235

Enrollment

Registered

2006-07-28

Start date

2006-07-28

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sugar type 2 diabetes mellitus

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All subjects: - Male sex - Age 50-65 years - BMI 27-35 kg/m2 - Stable dietary habits and physical activity levels;For diabetic patients only: - Must be on sulphonylurea- or metformin therapy for at least six months with a constant dose for at least two months, or on dietary treatment for at least six months - Well-controlled diabetes: fasting plasma glucose concentration must be

Exclusion criteria

Exclusion criteria: - Female sex - Unstable body weight (weight gain or loss > 3 kg in the past three months) - Participation in an intensive weight-loss program or vigorous exercise program during the last year before the start of the study - Active cardiovascular disease - liver disease of liver dysfunction (ALAT>2.5 x increased) - renal dysfunction - systolic blood pressure >160 mmHg or diastolic blood pressure > 100 mmHg - haemoglobin

Design outcomes

Primary

Measure	Time frame
DAG levels, ATGL protein content, insulin sensitivity, lipid accumulation and mitochondrial functioning in cardiac muscle and skeletal muscle.	—

Secondary

Measure	Time frame
Plasma free fatty acids, basal glucose level, body composition, VO2max.	—

Countries

Netherlands

Outcome results