Effect of ammonium compounds in tobacco on the nicotine absorption in smokers

Effect of ammonium compounds in tobacco on the nicotine absorption in smokers - Human ammonium study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON30221

Enrollment

Registered

2006-11-10

Start date

2006-12-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

verslaving Addiction habituation

Interventions

Smoking of a cigarette with a high ammonium-content and a cigarette with a low ammonium-content.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 18-50 years of age; Good health; Smoking more than 20 cigarettes or fine-cut tobacco (roll-yor-own) per day; Inhale during smoking.

Exclusion criteria

Exclusion criteria: Use of medicines, except oral contraconceptives or replacement hormones; Use of nicotin-containing products; Pregnancy or lactation; History of psychiatric problems/conditions; History of cardiac and pulmonary conditions.

Design outcomes

Primary

Measure	Time frame
The endpoint is nicotine and cotinine determinations in blood. Secundairy parameters are nicotine and cotinine determinations in saliva, exposure-related parameters (carboxyhaemoglobin, NNAL en NNAL-glucuronide, thiocyanate en acetonitrile) in blood, exposure-related parameters (acetonitrile and nitric monoxide) in exhaled breath, and bloodpressure and heartfrequency.	—

Secondary

Measure	Time frame
Secundairy parameters are nicotine and cotinine determinations in saliva, exposure-related parameters (carboxyhaemoglobin, NNAL en NNAL-glucuronide, thiocyanate en acetonitrile) in blood, exposure-related parameters (acetonitrile and nitric monoxide) in exhaled breath, and bloodpressure and heartfrequency.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)