Mechanisms of immune selection of GPI-deficient hematopoietic stem cells in paroxysmal nocturnal hemoglobinuria (PNH)

Mechanisms of immune selection of GPI-deficient hematopoietic stem cells in paroxysmal nocturnal hemoglobinuria (PNH) - PPNH06

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30207

Enrollment

Registered

2007-03-12

Start date

2007-02-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Paroxysmal nocturnal hemoglobinuria

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: PNH patients Aplastic anemia patients with a clone of blood cells with deficient expression of GPI-anchored proteins Age 18 years or older Informed consent

Exclusion criteria

Exclusion criteria: Not capable of determining will

Design outcomes

Primary

Measure	Time frame
in vitro susceptibility of hematopoietic stem cells of PNH and aplastic anemia patients and a clone of blood cells with deficient expression of GPI-anchored proteins for cytotoxic lysis.	—

Secondary

Measure	Time frame
The presence of autoreactive T, NK and NKT cell populations in blood of PNH and aplastic anemia patients with a clone of blood cells with deficient expression of GPI-anchored proteins.	—

Countries

Netherlands

Outcome results