Exercise-induced oxidative stress and peripheral muscle dysfunction in COPD; single-leg ergometer test versus whole-body exercise test.

Exercise-induced oxidative stress and peripheral muscle dysfunction in COPD; single-leg ergometer test versus whole-body exercise test. - Exercise-induced oxidative stress in COPD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30201

Enrollment

Registered

2006-09-25

Start date

2006-12-28

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic lung disease COPD

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -Diagnosis of COPD according to the American Thoracic Society (ATS) guidelines -No respiratory tract infection or exacerbation of their disease for at least 4 weeks before the study

Exclusion criteria

Exclusion criteria: -Smokers -Use of oxygen supplementation -Other chronic diseases such as rheumatoid arthritis, chronic colitis and diabetes -Cardiovascular diseases, renal diseases, liver diseases or mental diseases

Design outcomes

Primary

Measure	Time frame
Various parameters of oxidative stress will be analyzed in blood, urine as well in exhaled breath. These pulmonary and systemic oxidative stress markers will be compared between COPD patients and healthy controls at rest and during exercise. Mechanical efficiency and endurance of the quadriceps femoris muscle in COPD versus healthy controls will be tested with the single-leg ergometer test.	—

Secondary

Measure	Time frame
To investigate possible determinants of quadriceps femoris muscle endurance (impairment of airway obstruction, exercise capacity, daily activity level, leg muscle strength, total body and leg FFM).	—

Countries

Netherlands

Outcome results