Maternal and embryonic determinants of recurrent embryo implantation failure after assisted reproductive techniques.

Maternal and embryonic determinants of recurrent embryo implantation failure after assisted reproductive techniques. - Failure of Implantation after Recurrent Embryo transfers Acroniem: FIRE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30147

Enrollment

Registered

2006-05-16

Start date

2006-07-17

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

recurrent implantation failure sterility

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Study group • Women who have not achieved a pregnancy, despite the consecutive transfer of at least 4 normal/ high quality embryos. o Cryo-thawed embryos, which are of normal/ high quality after thawing are also included. o An abortion/ E.U.G. will be regarded as a pregnancy.;Reference group • Women who conceived after the first or second embryo transfer during ICSI treatment for male factor infertility and who have delivered a healthy baby.

Exclusion criteria

Exclusion criteria: Study group • PESA (percutaneous epididymal sperm aspiration) / MESA (microsurgical epididymal sperm aspiration / TESE (testicular sperm extraction) • Difficulty in communicating in Dutch or English • Women older than 37 years;Exclusion criteria for endometrial secretion aspiration: • Excisional procedures to treat cervical intraepithelial neoplasia and no previous uncomplicated ET. • Previous documented difficult embryo transfer ;Reference group • Use of oral anticonceptives/ IUD • Breastfeeding

Design outcomes

Primary

Measure	Time frame
The main study parameters are: • Uterine Natural Killer cell count in follicular phase endometrial biopsy (PEPSI) • Uterine Natural Killer cell count in luteal phase endometrial biopsy • The embryo secretion cytokine expression profile • The endometrial secretion cytokine expression profile before embryo transfer. The main study endpoint is: • Recurrent implantation failure	—

Secondary

Measure	Time frame
The secondary study parameters are: • Lifestyle factors: physical exercise, smoking, use of caffeine and alcohol, BMI (body mass index). • Blood parameters: anticardiolipin antibodies, lupus anticoagulant, Factor V Leiden mutation, prothrombin gene mutation, deficiencies in protein S, protein C, and antithrombin, TSH (when abnormal FT4 as well), basal FSH. • The pulsatility index of the a. uterina before ET. The secondary study endpoint are: • Number of embryos transferred • Number of embryo transfers	—

Measure

Time frame

The secondary study parameters are: • Lifestyle factors: physical exercise, smoking, use of caffeine and alcohol, BMI (body mass index). • Blood parameters: anticardiolipin antibodies, lupus anticoagulant, Factor V Leiden mutation, prothrombin gene mutation, deficiencies in protein S, protein C, and antithrombin, TSH (when abnormal FT4 as well), basal FSH. • The pulsatility index of the a. uterina before ET. The secondary study endpoint are: • Number of embryos transferred • Number of embryo transfers

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Countries

Netherlands

Outcome results