Late Adverse effects in Dutch testicular cancer survivors: a Nationwide case-control study on Cardiovascular Events (LANCE study)

Late Adverse effects in Dutch testicular cancer survivors: a Nationwide case-control study on Cardiovascular Events (LANCE study) - LANCE-study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30146

Enrollment

300

Registered

2006-07-18

Start date

2006-09-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiovascular disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: For all participants: - 18 years and older - treatment for non-seminomatous testicular cancer between 1977 and 1996 - age of 50 years or younger at start of initial treatment - at least 5 years after treatment;For cases: - diagnosis of a major cardiac event (myocardial infarction or proven coronary artery disease) at least 5 years after treatment for testicular cancer

Exclusion criteria

Exclusion criteria: For all participants: - treatment with mediastinal radiotherapy;For controls: - no diagnosis of a major cardiac event (myocardial infarction or proven coronary artery disease) after treatment for testicular cancer

Design outcomes

Primary

Measure	Time frame
The primary study parameters consist of cardiovascular risk factors that are evaluated by physical examination and analysis of blood and urine. Examples are obesity, hypertension, hypercholesterolaemia and albuminuria.	—

Secondary

Measure	Time frame
The secondary study parameters consist of genetic polymorphisms that are potentially involved in long-term cardiovascular toxicity following treatment for testicular cancer. In addition, quality of life following treatment for testicular cancer will be assessed by means of a questionnaire.	—

Countries

Netherlands

Outcome results