Phenotype and number of regulatory T cells present in peripheral blood of COPD patients versus healthy controls

Phenotype and number of regulatory T cells present in peripheral blood of COPD patients versus healthy controls - Regulatory T cells in COPD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30145

Enrollment

Registered

2006-09-12

Start date

2006-12-07

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic bronchitis COPD Emphysema

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: COPD patients • Clinical diagnosed COPD • FEV1 40 • > 10 pack years • Ex-smokers have to have quitted smoking for at least one year • No other health problems • Informed consent;Healthy controls: • No signs of pulmonary disease • No other health problems • FEV1 > 90 % predicted, FEV1/FVC > 70% • Age > 40 • Smokers and ex- smokers > 10 pack years • Never smokers, i.e. no cigarettes last year, and maximal 5 pack years • Ex-smokers have to have quitted smoking for at least one year • Informed consent

Exclusion criteria

Exclusion criteria: • Use of (inhaled) corticosteroids in the 6 weeks preceding the study • Problems with alcohol or drugs • COPD exacerbation in the 6 weeks preceding the study

Design outcomes

Primary

Measure	Time frame
1. Treg numbers in peripheral blood of COPD patients vs healthy controls 2. Expression patterns of HO-1, TGFβ and Smad 7 in Tregs from COPD patients vs healthy controls 3. Functional capacity of Tregs from COPD patients vs healthy controls 4. Involvement of TGFβ signalling in suppresive function of Tregs from COPD patients vs healthy controls	—

Secondary

Measure	Time frame
1. Effects of smoking history on above described parameters	—

Countries

Netherlands

Outcome results