Pathofysiology of postural instability in patients with distal and proximal myopathy

Pathofysiology of postural instability in patients with distal and proximal myopathy - Balance in myopathy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30142

Enrollment

Registered

2006-11-10

Start date

2006-10-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Distal or proximal myopathy muscle diseases

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Symmetrical proximal myopathy Symmetrical distal myopathy

Exclusion criteria

Exclusion criteria: Other disorders or medication that could influence balance control.

Design outcomes

Primary

Measure	Time frame
Balance in myopathy patients compared to healthy controls during external perturbations of the platform (expressed in Center of Mass displacement). Prediction: Proximal myopathy patients will have greatest instability for roll perturbations. Distal myopathy patients will have greatest instability for pitch perturbations.	—

Secondary

Measure	Time frame
1 Limb, pelvis, and trunk movements from 18 different sensor locations, measured during perturbations of the platform in patients with myopathy compared to healthy controls. Prediction: Instability on the platform is associated with abnormal knee, pelvis and lower trunk movements in patients with a proximal weakness and associated with abnormal ankle movements in patients with a distal weakness. 2 Muscle activity of ten muscles during perturbations of the platform, measured with surface electromyography. Prediction: Instability is associated with decreased amplitudes of proximal (trunk, hip) muscles in proximal myopathy and with decreased amplitudes of distal (lower leg) muscles in distal myopathy patients.	—

Measure

Time frame

1 Limb, pelvis, and trunk movements from 18 different sensor locations, measured during perturbations of the platform in patients with myopathy compared to healthy controls. Prediction: Instability on the platform is associated with abnormal knee, pelvis and lower trunk movements in patients with a proximal weakness and associated with abnormal ankle movements in patients with a distal weakness. 2 Muscle activity of ten muscles during perturbations of the platform, measured with surface electromyography. Prediction: Instability is associated with decreased amplitudes of proximal (trunk, hip) muscles in proximal myopathy and with decreased amplitudes of distal (lower leg) muscles in distal myopathy patients.

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Countries

Netherlands

Outcome results