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The Impact of Intraoperative Carbon Dioxide Wound Ventilation on Cerebral Microembolic Load during Aortic Arch Surgery : a Prospective Randomized Clinical Trial using Transcranial Doppler Ultrasound

The Impact of Intraoperative Carbon Dioxide Wound Ventilation on Cerebral Microembolic Load during Aortic Arch Surgery : a Prospective Randomized Clinical Trial using Transcranial Doppler Ultrasound - Carbon Dioxide Micro-Embolism Study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON30090
Enrollment
30
Registered
2006-08-24
Start date
2006-09-01
Completion date
Unknown
Last updated
2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

(minor cognitive function major or silent stroke) paralysis postoperative stroke

Interventions

In one group carbon dioxide surgical field flooding is used intraoperatively and in the other group not

Sponsors

St. Antonius Ziekenhuis
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: all patients accepted for elective surgery on the ascending aorta and aortic arch via median sternotomy

Exclusion criteria

Exclusion criteria: - emergency operation (including type A dissection) - patients with a difficult transtemporal acoustic ultrasound *bone window* - patients with claustrophobia and therefore unwilling to have magnetic resonance brain imaging or that have other contra-indications for this investigation (pacemakers, etc.) - patients with a more than 60% stenosis or occlusion of one or both carotid arteries - intraoperative technical failure of TCD registration

Design outcomes

Primary

MeasureTime frame
Number of cerebral microemboli counted on Transcranial Doppler ultrasound recordings

Secondary

MeasureTime frame
Postoperative ischemic reactions in the brain assessed by diffusion-weighted magnetic resonance imaging of the brain

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)