Psychiatrische stoornissen: Bipolar Disorder (Manisch-Depressiviteit) Affective Disorder Manic-Depressive Disorder
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients: 1) Part of a monozygotic or dizygotic twin pair 2) For monozygotic twin pairs at least one twin (MZ concordant and MZ discordant) and for dizygotic twin pairs only one twin (DZ discordant) has a diagnoses (life time): - Bipolar Disorder I or Bipolar Disorder II (DSM-IV criteria) - For the interview and blood sample: not in a acute (hypo)manic or major depressive episode 3) Age between 18 and 60 years;Healthy controls: 1) Part of a monozygotic or same-sex dizygotic twin pair 2) Matched to patient groups on age, sex and zygosity 3) Age between 18 and 60 years
Exclusion criteria
Exclusion criteria: Patients: 1) No history of drug or alcohol dependency (DSM-IV criteria) for the last half year 2) No history of Cognitive Disorder (DSM-IV criteria) 3) No history of serious neurological illness 4) No severe medical illness Healthy controls: 1) No history of specific axis I psychiatric disorder (DSM-IV criteria), on the basis of a SCID interview (Modules A-G) 2) No history of axis II personality disorder (DSM-IV criteria), on the basis of SIDP-V 3) No first degree relative with a history of specific axis I psychiatric disorder (DSM-IV criteria), on the basis of a FIGS interview 4) No history of serious neurological illness 5) No severe medical illness 6) No history of drug or alcohol dependency (DSM-IV criteria) for the last half year
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| - Diagnosis. Do patients have more and larger structural brain abnormalities compared to healthy control twin pairs, but also compared to their (healthy) co-twin. - Zygosity: Do patients have more and larger structural brain abnormalities compared to healthy control twin pairs and is there a difference between mono- and dizygotic twin pairs. - Sexe. Is there a difference in structural brain abnormalities between males and females. | — |
Primary
| Measure | Time frame |
|---|---|
| - Volume changes across time: Volume change within subjects, in patients as well as in (healthy) co-twins and healthy control twin pairs. This means the difference in brain volumes for T0 and T5 (in years). | — |
Countries
Netherlands
Outcome results
None listed