pro-hepcidin and hepcidin levels in blood and urine of Gaucher patients in relation to iron homeostasis.

pro-hepcidin and hepcidin levels in blood and urine of Gaucher patients in relation to iron homeostasis. - Iron homeostasis in Gaucher patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30063

Enrollment

Registered

2006-11-13

Start date

2006-09-15

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gaucherdisease and glucocerebrosidase deficiency

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -Patients, older than 18 years, with proven GD I, as evidenced by decreased plasma glucocerebrosidase activity or genotyping. -Controls, older than 18 years with a normal total iron binding capacity in blood. -Patients with proven Hematochromatosis as evidenced by total iron bindingcapacity of > 45% in blood or genotyping. -Patients and controls have to provide written informed consent to participate in the study.

Exclusion criteria

Exclusion criteria: none

Design outcomes

Primary

Measure	Time frame
Hepcidin in urine (SELDI-TOF MS) Pro-hepcidin in blood (ELISA)	—

Secondary

Measure	Time frame
In blood: sedimentation rate of erythrocytes, C-reactive protein, white blood count, creatinin, iron, ferritin, hemoglobin, erythrocyes MCV and total-iron-binding-capacity. In urine: hepcidin (SELDI-TOF MS) and creatinin.	—

Countries

Netherlands

Outcome results