The effect of hormonal replacement therapy on menopausal complaints related to biochemical changes in surgically and naturally postmenopausal women. A prospective observational comparative study.

The effect of hormonal replacement therapy on menopausal complaints related to biochemical changes in surgically and naturally postmenopausal women. A prospective observational comparative study. - HRT at surgical menopause

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30054

Enrollment

280

Registered

2006-09-19

Start date

2006-09-25

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

menopause

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: gr 1) Eligible to undergo PBSO Either proven BRCA 1 or BRCA 2 mutation carrier or member of an HBOC- family gr 2) Last menses >3 months ago Menopausal complaints gr 3) Age>=46 and 3 months,

Exclusion criteria

Exclusion criteria: gr 2 : Hormone use (contraceptives or HRT)

Design outcomes

Primary

Measure	Time frame
Endocrine symptoms score Hot flush score Estrogens, Testosterone, DHEAS, Serotonine, 5-HT2A-receptor	—

Secondary

Measure	Time frame
Sexual functioning score Depression and anxiety score Progesterone, LH, FSH, Cortisol, SHBG, Prolactin, Oxytocin, Catecholamines and β-Endorphin	—

Countries

Netherlands

Outcome results