inactiviteit: risicofactor voor atherosclerose inactivity
Conditions
Interventions
The intervention consists of 3 weeks of immobilisation of one leg. This will be
done by elevation of the active foot by a sole and fixing of the foot by belts
to the upper body, in a way the foot do
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Man 2. Aged 18-30 jr 3. Healthy (to own saying) 4. Non smoker 5. BMI >19 and
Exclusion criteria
Exclusion criteria: 1. Performing sports for over 5 hours a week 2. Hypertension (DBP>90, SBP>140) 3. Increased level of D-Dimer in blood plasma 4. Physical condition preventing measurement of maximal oxygen consumption 5. Recent fracture of a limb 6. Cardiovascular, musculo-skeletal, metabolic, hormonal or chronic diseases 7. Use of medication with possible hemodynamic effects 8. History of medical or surgical events that might have any influence on the results
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression of specific genes in the NO pathway (mRNA). | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional vascular characteristics as blood flow and systolic and diastolic vessel diameter of the carotid artery, the brachial artery and the superficial femoral artery; flow mediated dilation (FMD) and dilation due to nitroglycerine (NMD) of the susperficial femoral artery; dilation after infusion of ACh and L-NMMA of the superficial femoral artery. Additionally, muscle function parameters as muscle force, rate of muscle force rise, relaxation time and muscle fatigue and bone function. | — |
Countries
Netherlands
Outcome results
None listed