Pharmacogenetics of pain and sedation in critically ill children .

Pharmacogenetics of pain and sedation in critically ill children . - Pharmacogenetics in children

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30003

Enrollment

800

Registered

2006-07-26

Start date

2006-10-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pijn en onrust pain and stress

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: Children with a need for sedation and/or analgesia.

Exclusion criteria

Exclusion criteria: Life expectancy less then 24 hours ECMO

Design outcomes

Primary

Measure	Time frame
Main study parameter is the difference in dosage requirements of sedatives and analgesics of patients with different genetic profiles for pain- and sedation related genes.	—

Secondary

Measure	Time frame
Population pharmacokinetic-pharmacodynamic (PK-PD) will be used for modeling to determine the impact of the polymorphisms on the relationship between dose, blood drug concentration (PK) and sedation scores (PD: COMFORT scale, VAS scale, BIS monitoring)	—

Countries

Netherlands

Outcome results