APOPTOSIS OF ALVEOLAR EPITHELIAL CELLS DURING MECHANICAL VENTILATION IN CHILDREN

APOPTOSIS OF ALVEOLAR EPITHELIAL CELLS DURING MECHANICAL VENTILATION IN CHILDREN - APACHI-study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON30000

Enrollment

100

Registered

2010-11-30

Start date

2006-08-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

programmed cell death in the lung pulmonary epithelial cell apoptosis

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: All children younger than 5 years of age who are admitted to the PICU for mechanical ventilation

Exclusion criteria

Exclusion criteria: - PaO2/FiO2 ratio 1.5 normal value - No permission form parents or care takers

Design outcomes

Primary

Measure	Time frame
Soluble death receptor ligands sFasL (relatively to sFas) and TNF*/TRAIL (by ELISA) Granzyme A and B, cleaved cytokeratin 18 (by M30 based ELISA) Active Angiotensin Coverting Enzyme and Angiotensin II as a parameter of death receptor apoptosis Total protein, IgM and Albumin, total cell and differential count.	—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results