Diagnosing expiratory flow limitation in COPD patietns with forced oscillation technique using linear regression in the time frequency domain

Diagnosing expiratory flow limitation in COPD patietns with forced oscillation technique using linear regression in the time frequency domain - FOT and EFL

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON29991

Enrollment

Registered

2006-10-11

Start date

2006-10-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung emfysema chronic bronchitis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All patients should meet the standard diagnostic criteria for COPD and they are current or ex-smokers. The subjects must have stable disease at the time of the inclusion, which means that they cannot have an exacerbation of the COPD during the 4 weeks previous to the inclusion

Exclusion criteria

Exclusion criteria: History of exacerbation of COPD in the preceding month Upper airway obstruction Allergic Asthma OSAS Extreme obesity (BMI>35) Pulmonary disease other than COPD Clinically manifest cardiac disease (for example clinically relevant congestive heart failure, unstable angina pectoris)

Design outcomes

Primary

Measure	Time frame
Xrs-8 (cmH20.s/L) (shorthand notation for the most negative value of Xrs during expiration at 8 Hz) Open or closed loop in pressure-volume loop measured by the body plethysmography	—

Secondary

Measure	Time frame
Spirometry: FEV1 (L), FVC (L), IC (L), VC max (L), CO-diffusion: TLCOSB, kCO Body plethysmography: RV (L) TLC (L) Forced oscillation technique: Xrs-12,16,20,24 (cmH20.s/L) Rrs-8,12,16,20,24 (cmH20.s/L) Phase-8,12,16,20,24 (degrees) Amplitude-8,12,16,20,24 (cmH20.s/L) Other study parameters Anthropometrical data	—

Countries

Netherlands

Outcome results