gezonde vrijwilligers nvt
Conditions
Interventions
On each testday volunteers recieve either of the following treatments:
dexchlorpheniramine 4 mg, lorazepam 1 mg or placebo.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Males and females Age 18-45 Good physical health as determined by a medical history questionnaire, medical screening by a physician, ECG and blood haematology Absence of any medical, endocrine and neurological condition Body mass index (weight/length2) between 18 and 28 kg/m2 Blood pressure between 100-150 Hg systolic and 60-90 Hg diastolic Written informed consent
Exclusion criteria
Exclusion criteria: History of or current drug abuse Current use of psychoactive medicinal treatment Drinking more than 20 alcoholic consumptions per week For females: pregnancy or lactation Drinking more than 5 cups of caffeinated drinks per day Smoking more than 5 cigarettes per day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reaction time in milliseconds as measured by the choice reaction time task, n-back memory task and word recognition task. The number of memorized words during the immediate recall phase and during the delayed recall (few minutes) phase (45 minutes). Number of correct detected letters in the n-back task. Average deviation from midline as measured by the sub-critical tracking task. The different ERP components: N100/P100, N200/P200, P300, CNV and LRP. | — |
Countries
Netherlands
Outcome results
None listed