Cartilage degeneration degenerative disease
Conditions
Interventions
None listed
Sponsors
Reumafonds
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Participation in the study "MRI triage for arthroscopy" 1997.
Exclusion criteria
Exclusion criteria: Pregnacy. Contraindications for MRI: pacemaker, implants etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective 1) To identify high risk patient groups for development of knee osteoarthritis (OA) in a cohort 9-10 years after meniscus, cruciate ligament and cartilage lesions. •Primary parameters: Kellgren-Lawrence Grading System for radiological OA of the knee. The Altman score for radiological OA of the knee. Objective 2) To determine the use of 3T MRI state of the art imaging in detecting early OA in the knee. •Kellgren-Lawrence Grading System for radiological OA and the Altman score for radiological OA of the knee compared to KOSS (Knee Osteoarthritis Score System) grading for OA in MRI. Objective 3) To determine if functionality of the knee is affected by arthroscopic intervention. •Primary parameters: Noyes and Tegner questionnaires for functionality of the knee. KOSS (Knee Osteoarthritis Score System) grading for OA in MRI. Objective 4) To determine if genetic predisposition (hand OA, family history) is associated with development of OA of the knee. •Primary parameters: DNA tests compared to the Kellgren-Lawrence Grading System for radiological OA and the Altman score for radiological OA of the knee | — |
Secondary
| Measure | Time frame |
|---|---|
| Objective 1) To identify high risk patient groups for development of knee osteoarthritis (OA) in a cohort 9-10 years after meniscus, cruciate ligament and cartilage lesions. •Secondary parameters: Knee injury and Osteoarthritis Outcome Score (KOOS), SF-36 generic health assessment questionnaire. Biomarkers in serum and urine: CTX-II, Glc-Gal-PYD, and PIIINP Objective 2) To determine the use of 3T MRI state of the art imaging in detecting early OA in the knee. •Secondary parameters: KOSS (Knee Osteoarthritis Score System) grading for OA in MRI compared to the Knee injury and Osteoarthritis Outcome Score (KOOS).Objective 3) To determine if functionality of the knee is affected by arthroscopic intervention. •Secondary parameters: Physical examination of instability, range of motion, crepitus and signs of inflammation of the knee. SF-36 generic health assessment questionnaire Objective 4) To determine if genetic predisposition (hand OA, family history) is associated with development of OA of the knee. •Secondary parameters: DNA tests compared to questionnaires for family history, physical examination and X-ray of the hand. | — |
Countries
Netherlands
Outcome results
None listed