Quantitative and qualitative determination of natural occuring regulatory t cells in blood and bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis and healthy volunteers.

Quantitative and qualitative determination of natural occuring regulatory t cells in blood and bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis and healthy volunteers. - Role of regulatory t cells in patients with pulmonary sarcoidosis.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON29919

Enrollment

Registered

2006-07-20

Start date

2007-02-27

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Besnier Boeck disease Sarcoidosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Clinical strong suspicion of sarcoidosis Alveolar lymphocytosis (>=15%) Histological confirmed sarcoidosis firstly presenting

Exclusion criteria

Exclusion criteria: previous steroid use , smoking

Design outcomes

Primary

Measure	Time frame
phenotypical analysis: 1 - expression of protein (absolute en percentual) 2 - intensity of protein expression per cel both in lavage-fluid and peripheral blood functional analysis: 1 - suppression of proliferation (%) 2 - cytokine measurement (concentration) in peripheral blood physiological analysis: measurement of auto-antibodies in peripheral blood genetic analysis: when abovementiones analyses show significant differences with respect to protein expression or cytokine production relevant genes (PTPN22, CTLA4, CD103, TGFβ-1) will be genotyped and screened for present polymorphisms.	—

Measure

Time frame

phenotypical analysis: 1 - expression of protein (absolute en percentual) 2 - intensity of protein expression per cel both in lavage-fluid and peripheral blood functional analysis: 1 - suppression of proliferation (%) 2 - cytokine measurement (concentration) in peripheral blood physiological analysis: measurement of auto-antibodies in peripheral blood genetic analysis: when abovementiones analyses show significant differences with respect to protein expression or cytokine production relevant genes (PTPN22, CTLA4, CD103, TGFβ-1) will be genotyped and screened for present polymorphisms.

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Countries

Netherlands

Outcome results