Unraveling the effects of rhythmic external cueing on mobility: synchronisation and use of alternative circuitry in the parkinsonian brain.

Unraveling the effects of rhythmic external cueing on mobility: synchronisation and use of alternative circuitry in the parkinsonian brain. - Unraveling cueing in parkinson's disease

Status

Active, not recruiting

Phases

Phase 2

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON29887

Enrollment

Registered

2006-12-08

Start date

2006-01-10

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's Disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients: 1) Modified Hoehn and Yahr stage ranging from 2 to 4; 2) a stable medication regime; All: 3) age under 70 years; 4) sufficient orientation in time and place (Minimal Mental State Examination (MMSE) * 26) , 5) completion of an informed consent for participation, and 6) able to walk 10 meter independently.

Exclusion criteria

Exclusion criteria: Patients: 1) Presence of severe dyskinesia (Modified Dyskinesia Scale score >1), All: 2) any (other) neurological, cardiovascular or orthopaedic disorder or other co-morbidity that may influence mobility and would interfere with participation ,3) presence of medical implants such as pacemakers, 4) inability to communicate (written of verbally) in the Dutch language and 5) history fo epilepsy

Design outcomes

Primary

Measure	Time frame
Group and condition differences in 1) localization, latency and amplitude of evoked cortical potentials, 2) spectral power over different frequency bands, 3) cortico-cortical synchronization patterns (e.g. interregional coupling or correlation, synchronization likelihood, coherence ), 4) blood oxygen level-dependent (BOLD) MRI signal changes.	—

Secondary

Measure	Time frame
Group differences in changes in performance on motor paradigm after rTMS (hand movement speed, timing of hand movement to cues and walking speed, cadence and stride length).	—

Countries

Netherlands

Outcome results