malignant left-sided colonic obstruction malignant obstruction of the left colon
Conditions
Interventions
Patients will be randomized to either emergency surgery (current standard
treatment) or colonic stenting as bridge to elective surgery.
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Symptoms of left-sided malignant colonic obstruction existing less than one week defined as obstructive symptoms with dilation of the colon on plain abdominal X-ray and typical abnormalities on a gastrografin enema study compatible with a malignant colonic stricture
Exclusion criteria
Exclusion criteria: *Peritonitis, perforation, fever, sepsis or other serious complications demanding urgent surgery *ASA IV or V *Obstruction due to non-colonic malignancies or from a benign origin *Distal tumor margin less than 10 cm from the anal verge *Incapable of completing self-report quality of life questionnaires
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will compare the effectiveness of both strategies. Effectiveness will be evaluated in terms of quality of life, morbidity and mortality. Quality of life will be measured with the following standardized questionnaires: EORTC QLQ-C30, the colorectal cancer specific EORTC QLQ-CR38 and the EuroQol. Morbidity is defined as every event leading to hospital admission or prolonging hospital stay. Mortality will be analyzed as total mortality as well as procedure-related mortality. | — |
Secondary
| Measure | Time frame |
|---|---|
| As secundary outcome parameters we will compare costs of both strategies. | — |
Countries
Netherlands
Outcome results
None listed