Dopaminergic modulation of neuronal response to a stimulus-reward task in people with 22q11 deletion syndrome and healthy volunteers: a functional MRI study.

Dopaminergic modulation of neuronal response to a stimulus-reward task in people with 22q11 deletion syndrome and healthy volunteers: a functional MRI study. - The role of dopamine in reward processing.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON29870

Enrollment

Registered

2006-10-30

Start date

2006-06-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

delusion psychosis

Interventions

Temporary acute dopamine depletion with alpha-metyrosine (AMPT).

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 20 individuals with 22q11 deletion syndrome with no psychiatric history and no use of psychiatric medication, age 18 till 50 years. 20 healthy volunteers, matched for age and gender, with no psychiatric history and no use of psychiatric medication.

Exclusion criteria

Exclusion criteria: Pregnancy, presence of metals that are not allowed in MRI-investigation.

Design outcomes

Primary

Measure	Time frame
Blood oxygen level dependent (BOLD) contrast measured during a modified reversal learning task within the MRI scanner.	—

Secondary

Measure	Time frame
1. Level of catecholamine synthesis, measured by blood levels of: * homovanillic acid (HVA) * 3-methoxy-4 hydroxyphenethyleneglycol (MHPG), * VMA * prolactine and urine levels of: * HVA * MHPG * VMA * dopamine (free and conjungated) and norepinephrine (free and conjungated) 2. Score on modified reversal learning taak 3. Possible extrapyramidal side-effects 4. Subjective experiences 5. Depressive and positive and negative symptoms	—

Measure

Time frame

1. Level of catecholamine synthesis, measured by blood levels of: * homovanillic acid (HVA) * 3-methoxy-4 hydroxyphenethyleneglycol (MHPG), * VMA * prolactine and urine levels of: * HVA * MHPG * VMA * dopamine (free and conjungated) and norepinephrine (free and conjungated) 2. Score on modified reversal learning taak 3. Possible extrapyramidal side-effects 4. Subjective experiences 5. Depressive and positive and negative symptoms

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)