Is long-term use of proton pump inhibitors associated with vitamin B12 deficiency in elderly individuals?

Is long-term use of proton pump inhibitors associated with vitamin B12 deficiency in elderly individuals? - PPIs and vitamin B12 deficiency in the elderly

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON29864

Enrollment

220

Registered

2006-07-03

Start date

2006-07-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cobalamin deficiency low vitamin B12 serum levels

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Individuals of 65 years and older that have had at least 810 Defined Daily Doses (DDD) of proton pump inhibitors in the last three years and live with their partner.

Exclusion criteria

Exclusion criteria: A couple will be excluded from study participation if the general practitioner indicates that one of the following characteristics apply to the user of proton pump inhibitors or partner: -vitamin B12 supplementation -folic acid supplementation -use of H2-blockers -use of antacids -known chronic alcohol abuse -cognitive impairment A couple will also be excluded when the partner uses proton pump inhibitors.

Design outcomes

Primary

Measure	Time frame
We will compare serum vitamin B12, folic acid and homocysteine between the two study groups. Results will be adjusted for possible differences in nutritional behavior and status, health status, use of vitamin supplements and helicobacter pylori status.	—

Secondary

Measure	Time frame
We will compare hemoglobin levels and mean corpuscular volumebetween the two study groups.	—

Countries

Netherlands

Outcome results