Intra tumoral Oxygenation; A Predictor for Treatment outcome in Cervical Cancer.

Intra tumoral Oxygenation; A Predictor for Treatment outcome in Cervical Cancer. - Tumor oxygenation in cervical cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON29843

Enrollment

Registered

2006-10-12

Start date

2006-08-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cervical cancer

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Histologically proven carcinoma of the uterine cervix (primary tumor: FIGO stages I-IV, or local recurrence), 2. Age >18 years, 3. Written informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients without a tumor accessible by vaginal inspection, 2. Patients with severe vaginal blood loss, 3. Patients with psychosocial or somatic disorders in the medical history limiting the possibilities for adequate follow-up, 4. Patients with a pacemaker or other metal objects not suitable for MRI 5. Patients unable to receive propofol anesthesia

Design outcomes

Primary

Measure	Time frame
1. feasibility of techniques 2. Oxygenation parameters (appendix 1: P50 value HP 2.5 HP 5.0 HP 10.0 Ktrans (exchange rate) Ve (extravascular volume) OER (Oxygen Extraction Ratio) Gene expression profiles HIF-1* CA-9 Lactate PAI-1 osteopontin D-dimer VEGF bFGF TGF-* TNF-* IL-8 Local control Failure free survival Overall survival Acute toxicity Late toxicity	—

Secondary

Measure	Time frame
Local control Failure free survival Overall survival Acute toxicity Late toxicity	—

Countries

Netherlands

Outcome results