Cardiovascular disease Hardening or furring of the arteries
Conditions
Interventions
None listed
Sponsors
Academisch Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Unstable angina (IIA, IIIA, IIB, IIIB-Tneg): Clinical symptoms secondary to recent coronary plaque rupture, history of recent unstable angina, ECG repolarization abnormalities, statin treatment (> 2 months). Stable angina patients: Stable atherosclerotic lesion(s) identified during coronary angiography, treated for more than 2 months for angina pectoris, statin treatment (> 2 months). Rheumatoid arthritis patients: Diagnosed as having Rheumatoid Arthritis for longer than 12 months, statin treatment (> 2 months).
Exclusion criteria
Exclusion criteria: Unstable angina (IIA, IIIA, IIB, IIIB-Tneg): Recent history of acute myocardial infarction (in the past year), elevated troponin-T levels, diabetic, smoker, under 18 yrs of age, clinical manifestation of extracardiac atherosclerotic disease. Stable angina patients: Recent history of unstable angina or Acute Myocardial Infarction, diabetic, smoker, under 18 yrs of age, clinical manifestation of extracardiac atherosclerotic disease. Rheumatoid arthritis: Clinical symptoms of atherslerotic disease, diabetic, smoker, under 18 yrs of age.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relative gene expression levels in monocytes from different inflammatory disease patient groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| A questionaire concerning the habits and the disease progression of the patients will be conducted. This will be used in later correlation studies. A folow-up questionaire will be taken after 12 months | — |
Countries
Netherlands
Outcome results
None listed