Brain activation during sentence processing in Parkinson's disease: an event related fMRI-study.

Brain activation during sentence processing in Parkinson's disease: an event related fMRI-study. - Language and Parkinson's disease.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON29824

Enrollment

Registered

2006-10-12

Start date

2006-10-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

onbekend

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Parkinson*s disease

Exclusion criteria

Exclusion criteria: dementia, depression, other neurological or psychiatric disorders

Design outcomes

Primary

Measure	Time frame
For the fMRI analysis data, a main effect of group is expected. The level of activation in the BG will be reduced in the PD patient group compared to the healthy control group. For the within subject factors we expect to find a main effect of grammaticality. In the healthy elderly subject group, we expect that the processing of the grammatical incorrect sentences will activate the BG more compared to the processing of the grammatical correct sentences. For the behaviourally data, we expect to find slower reaction times (RTs) for the processing of non-canonical ungrammatical sentences (i.e. passive sentences with a violation) in both subject groups. However the RTs will be significantly more affected in the PD group compared to the healthy elderly subject group.	—

Measure

Time frame

For the fMRI analysis data, a main effect of group is expected. The level of activation in the BG will be reduced in the PD patient group compared to the healthy control group. For the within subject factors we expect to find a main effect of grammaticality. In the healthy elderly subject group, we expect that the processing of the grammatical incorrect sentences will activate the BG more compared to the processing of the grammatical correct sentences. For the behaviourally data, we expect to find slower reaction times (RTs) for the processing of non-canonical ungrammatical sentences (i.e. passive sentences with a violation) in both subject groups. However the RTs will be significantly more affected in the PD group compared to the healthy elderly subject group.

—

Secondary

Measure	Time frame
Not applicable!	—

Countries

Netherlands

Outcome results