transient endocrine disruption/ hormone dysregulation
Conditions
Interventions
The intervention studied is a single intake of 50 grams of soy nuts, which are
available at a Herbalife reform shop and contain approximately 75 mgs of
phyto-estrogens, which corresponds with a trad
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Healthy men - Age 18 - 25 - BMI 18.5 - 25
Exclusion criteria
Exclusion criteria: - use of anti-coagulants - diagnosis diabetes, thyroid disorder or other chronic illness that potentially involves a disturbed endocrine system - use of hormonal medication - chronic kidney or liver disorder - use of antibiotics three months before the experiment - use of meat or dairy substitutes at least two times a week for the last six months - soy allergy - smoking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of the study is the total serum estrogenic activity measured with the ER-CALUX assay and expressed in estradiol equivalents (EEQs). | — |
Secondary
| Measure | Time frame |
|---|---|
| Information will be collected about background variables and potential confounders, such as age, BMI, and consumed foodstuffs and potential gastro-intestinal problems during the study. | — |
Countries
Netherlands
Outcome results
None listed