Impaired cerebral autoregulation in patients with sickle cell disease

Impaired cerebral autoregulation in patients with sickle cell disease - Cerebral autoregulation in SCD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON29798

Enrollment

Registered

2006-08-30

Start date

2006-09-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sickle cell disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - proven sickle cell disease - age between 18-35

Exclusion criteria

Exclusion criteria: - HbSC - History of stroke - Hypertension (systolic >160 mm Hg or diastolic >100 mm Hg) - Blood transfusion in the preceding four weeks - Sickle cell crisis in the preceding two weeks

Design outcomes

Primary

Measure	Time frame
Cerebral blood flow velocity, cerebral oxygenation and cerebrovascular CO2 responsiveness (as the percentage increase in MCA Vmean per mmHg increase in PetCO2).	—

Secondary

Measure	Time frame
Autonomic cardiovascular function (blood pressure, cardiac output and derived parameters)testing using the Ewing*s test battery (a set of short physical exercises: e.g. vassalva maneuver and deep breathing) is used to measure parasympathetic heart rate control, sympathetic cardiovascular control.	—

Countries

Netherlands

Outcome results