Changes of Effective Downstream Pressure (EDP) and Cerebral Perfusion Pressure (CPP) under influence of hypnotics and volatile narcotics. A prospective, randomised, double-blinded trial.

Changes of Effective Downstream Pressure (EDP) and Cerebral Perfusion Pressure (CPP) under influence of hypnotics and volatile narcotics. A prospective, randomised, double-blinded trial. - Effective Downstream Pressure (EDP) - influence of anesthetics.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON29763

Enrollment

Registered

2006-06-28

Start date

2007-01-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cerebraal-vasculaire vaatweerstand, autoregulatie hersenen blood pressure brain perfusion cerebral effective dowstream pressure

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Patients planed for surgical produre in general anaesthesia - no intracranial surgery - written informed consent - 18 to 60 years old - physical status ASA 1-2 - no history of cerebral illnes or cebrebrovascular deseases - no medication with vasoactive therapeutics (betabloker, alphabloker, nitrates, molsidomine, ACE-inhibitors, Ca-Antagonist, diuretics)

Exclusion criteria

Exclusion criteria: - any cerebrovascular disease in history - any history of cerebrovascular spasm - any brain trauma in history - any intracrainial neoplasma/tumor in history - patients who cannot comunicate in Dutch or English language

Design outcomes

Primary

Measure	Time frame
- EDP	—

Secondary

Measure	Time frame
- CPPedp (mmHg) - Autoregulation phase relation between Vmca and the arterial pressure curve, (ms) - Difference between EDC calculation (Belford et al.) (mmHg) and instantanious EDP measurement (Weyland et al.) (mmHg)	—

Countries

Netherlands

Outcome results