Hippocampal blood flow and electroconvulsive therapy in depression

Hippocampal blood flow and electroconvulsive therapy in depression - Hippocampal blood flow and electroconvulsive therapy in depression

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON29749

Enrollment

Registered

2006-08-01

Start date

2006-09-30

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression Depressive disorder

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients who meet DSM-IV criteria for depressive disorder and meet the Dutch Psychiatric Association criteria for electroconvulsive therapy. Healthy control subjects who do not meet any DSM-IV criteria. Age between 18 and 65.

Exclusion criteria

Exclusion criteria: Patients who do not meet DSM-IV criteria for depressive disorder. Healthy controls who meet the criteria for a DSM-IV diagnosis. Subjects who have severe cognitive impairments (e.g. vascular or Alzheimers dementia), severe medical conditions (e.g. coronaire heart disease, COPD, diabetes), non removable metal objects. Subjects who are pregnant or lactating.

Design outcomes

Primary

Measure	Time frame
The primary study parameter will be changes in hippocampal blood flow as a result of ECT measured in ml/min/100g	—

Secondary

Measure	Time frame
Differences in hippocampal bloodflow between depressed patients and healthy controls measured in ml/min/100mg. Changes in depression score before and after ECT treatment as measured by means of the Hamilton depression rating scale.	—

Countries

Netherlands

Outcome results